Stager-D3 50,000 IU Capsule
Vitamin D (D3, Cholecalciferol) 50,000 IU 

ALL DETAILS ABOUT STAGER VITAMIN D3:

Stager-D3 5 000 IU, Stager-D3 10 000 IU, Stager-D3 25 000 IU, Stager-D3 50 000 IU

THERAPEUTIC CLASSIFICATION
Vitamin

PHARMACOLOGY:
Vitamin D is a fat-soluble vitamin that helps regulate serum calcium and phosphorous concentrations by enhancing the efficiency of the small intestine to absorb these minerals from the diet. The term Vitamin D collectively refers to a group of structurally similar chemicals and their metabolites, which includes alfacalcidol (1α-hydroxycholecalciferol), calcitriol (1,25- dihydroxycholecalciferol), cholecalciferol· (Vitamin D3), dihydrotachysterol (DHT) and ergocalciferol (Vitamin D2). These agents have antirachitic properties.
In human beings there is no practical difference between the biologic activity of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2). One microgram (μg) of either compound is equivalent to 40 IU of vitamin D activity. Vitamin D is essential for the absorption and utilization of (calcium and phosphate and aids in the mobilization of bone calcium and maintenance of serum calcium concentrations.
In humans, cholecalciferol (vitamin D3) is synthesized in the skin, from7-dehydrocholesterol, on exposure to ultraviolet radiation. Cholecalciferol is also present in fish, liver oils, Ergocalciferol (vitamin D2) is produced by ultraviolet irradiation of provitamin D sterol (ergosterol).
Ergosterol is not synthesized in humans but is consumed in the diet from yeasts and plants.
Cholecalciferol and ergocalciferol are hydroxylated in the liver by the enzyme vitamin D-25- hydroxylase to form 25-hydroxycholecalciferol (calcifediol) and 25-hydroxyergocalciferol respectively. These compounds undergo further hydroxylation in the kidneys by the enzyme vitamin D-hydroxylase to form the active metabolites 1,25-dihydroxycholecalciferol (calcitriol) and 1,25-dihydroxyergocalciferol respectively. These are the primary active metabolites of cholecalciferol and ergocalciferol, respectively (Source: Gilman). Dihydrotachysterol is produced by synthetic reduction of ergocalciferol. Patients with chronic renal disease cannot convert calcifediol to calcitriol. Alfacalcidol (1α-hydroxyvitamin D3), a synthetic analogue of calcitriol, is rapidly converted in the liver to calcitriol, bypassing the renal conversion step. Because alfacalcidiol, calcitriol and dihydrotachysterol do not require renal hydroxylation, they are useful in patients with renal failure.

PHARMACOKINETICS:
Vitamin D analogues are readily absorbed from the small intestine if fat absorption is normal.
Bile is required for absorption. As described previously, cholecalciferol and ergocalciferol are converted. To active metabolites through a two-step hydroxylation process, the first occurs in the liver and the second occurs in the kidney.
Dihydrotachysterol and alfacalcidol are converted to their active metabolites in the liver. The liver activates Dihydrotachysterol and alfacalcidol. Vitamin D is eliminated renally and by biliary excretion.

INDICATIONS:
Stager-D3 5 000 IU, Stager-D 10 000 IU, Stager-D 25 000 IU, Stager-D 50 000 IU are indicated for:
Treatment and Prevention of Vitamin D Deficiency
Support of Bone and Musculoskeletal Health
Immune System Support and Modulation
Treatment of Refractory Rickets (Vitamin D–Resistant Rickets)
Treatment of Hypoparathyroidism
 
CONTRAINDICATIONS:
Stager-D3 5 000 IU, Stager-D 10 000 IU, Stager-D 25 000 IU, Stager-D 50 000 IU should not be used in patients with:
known hypersensitivity to Vitamin D or any of its analogues and derivatives
High levels of calcium in your blood (hypercalcaemia).
malabsorption syndrome
abnormal sensitivity to the toxic effects of Vitamin D
High levels of vitamin D in your blood (Hypervitaminosis D)
Have kidney stones or serious kidney problems
 
ADVERSE EFFECTS:
Vitamin D3 (cholecalciferol) is generally well tolerated in doses that do not exceed the
recommended daily intake. Chronic excessive dosing can lead to toxicity (see precautions).
 
Possible side effects 
Hypercalcaemia (too much calcium in your blood). 
 
How to take Stager D3:
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

DOSAGE:
At the higher doses of Vitamin D used for active treatment, the range between therapeutic and toxic doses is narrow. The dosage of vitamin D3 must be individualized with careful monitoring of serum-calcium levels. Readjust therapeutic dosage as soon as there is clinical improvement.
Careful titration is necessary to avoid overdose. Dietary and other sources of vitamin D must be considered. Calcium intake should be adequate.

For treatment of Vitamin D resistant rickets: 12 000 to 500 000 IU (0.3 to 12.5mg) daily.
For treatment of hypoparathyroidism: 50 000 to 200 000 IU (1.25 to 5.0 g) daily.

Calcium supplementation is also required.
A specialist must be consulted in the treatment of Hypophosphatemia, Hypocalcemia, Renal Osteodystrophy, and Corticosteroid induced Osteoporosis.
 
Warnings:
Do not use this medicine after the expiry date which is stated on the blister strip or bottle after EXP. The expiry date refers to the last day of that month. There is no evidence of an allergen. Do not exceed recommended daily doses, unless it is recommended by a doctor. If you are already taking any medications, please consult your doctor or pharmacist. 

STORAGE CONDITION:
✓ Store out of children's reach and sight.
✓ Keep in room temperature, below (25 °C) in a dry place. Protect from heat and light.