MEFOLAT TABLET
 
WHAT MEFOLAT IS AND WHAT IT IS USED FOR: 
MEFOLAT Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced and active form of folate found in our bodies. 
Quatrefolic® is the fourth-generation folate, providing higher stability, better water solubility, and flexibility for multiple ingredient formulations compared to a third-generation 5-MTHF calcium salt and immediately able to penetrate the blood and the cell membrane without further metabolism.
 
INDICATIONS OF MEFOLAT:
From the time the human egg is fertilized, through the development of the brain, heart, and other organs, to birth, and throughout a person's lifespan, methylfolate is required.
•Provide the nutritionally active form of folate during preconception, pregnancy and lactation.
•Contributes to maternal tissue growth during pregnancy.
•Supports pregnancy by reducing the risk of neural tube defects.
•Improving fertility, and increasing success rates in infertility treatment.
•Might offer protection against mood impairment during pregnancy and postpartum.
 
PROPERTIES OF MEFOLAT (QUATREFOLIC®):
•Improve high bioavailability and water solubility, as well as long-lasting chemical stability.
•Lesser first pass metabolism.
•Remain active in the body for longer duration.
•Effective distribution throughout the body.
•Is generally recognized as safe (GRAS) for use as a source of folate in conventional & medical foods.
•Active even in presence of MTHFR polymorphism. •It is the only form of folate directly crosses the BBB.
 
SUGGESTED INTAKE:
Adults:
As a dietary supplement, take one tablet daily with water or as directed by a healthcare practitioner
 
L-METHYLFOLATE (QUATREFOLIC®):
Is the 4th generation of folate that:
-Provide the active form of folate naturally present in the body and available for biological action.
-L-Methylfolate improve high bioavailability.
-It is the only form of folate that directly crosses the Blood Brain Barrier.
 
Quatrefolic® vs. Folic Acid:
The body can’t just use folic acid as it is—it has to go through a conversion process into a form called Methyltetrahydrofolate, or MTHF, in order to use it. Quatrefolic® doesn’t go through the same conversion process as folic acid, effectively bypassing that genetic variation.
 
HEALTH BENEFITS:
Fertility: Quatrefolic® can make a difference, bypassing folate metabolism disturbances, improving fertility, and increasing success rates in infertility treatment.
Pregnancy: Provide the nutritionally active form of folate during preconceptions, pregnancy and lactation. The demand for folate increases when human cell growth is very active, such as in pregnancy. Studies have found that low dietary intake of folate increases the risk of delivering a child with several types of birth defects, particularly neural tube defects (NTD) and possibly leading to poor growth in the fetus or placenta.
Menopause: Quatrefolic® supplementation may help postmenopausal women to normalize homocysteine, contributing to helping hot flashes, cardiovascular and bone health of aging women.
Cardiovascular: Quatrefolic® offers a homocysteine-lowering and -normalizing effect clinically proven.
Cognition: Quatrefolic® supplementation is suggested to guarantee the right dosage of biologically active folate and to efficiently support brain function since it is the only folate form able to cross the blood-brain barrier.
Infant and Children: Quatrefolic® sustains healthy cell, tissue growth, digestive, and immune systems. It can improve energy production and the formation of red blood cells while promoting normal brain development and function. Moreover, the 5-MTHF can boost learning ability and memory. Quatrefolic® use levels will be the same as that of folate.
 
WHAT HAPPENS IF PREGNANT WOMEN FOLATE IS LOW?
In pregnant women, the consequences of a folic acid deficiency are dramatic: anomalies in the development of maternal tissues (placenta, blood circulation) and fœtus (birth neural tube defects – NTDs – like spina bifida and anencephaly), delayed growth of the fœtus, an increase in the risk of premature births, low folate reserves in infants. From adolescence, the female population should thus ensure that its needs for folic acid are met.
 
CLINICAL RESEARCH EMPHASIZES THE IMPORTANCE OF FOLATE SUPPLEMENTATION IN:
Neural-tube defects (NTDs)
Male and female infertility
Spontaneous abortion
Coronary heart disease
Macrocytic anemia
Methotrexate therapy
Epilepsy
Irritable bowel disease
Cognitive deficits in elderly
Lifestyle putting people at risk of low folate levels: Smoking, Alcohol excess, Eating disorders, Low-vegetable intake, Chronic dieting.
 
WARNINGS:
Do not use for children under 3 years of age. Do not use in case of allergy to the ingredients. Do not exceed recommended daily doses, unless it is recommended by a doctor. If you are already taking any medications, please consult your doctor or pharmacist.
 
STORAGE CONDITIONS:
Store below 30°C, in a dry place.
Protect from light and moisture.
Keep it out of the reach of children.
 
FREE FROM:
(Vegan, GMO, gluten, lactose, sugar, preservative, parabens, sodium, and flavors).